Research from Analysis Proposal:
Study Methods
On the current period, no clinical studies have already been conducted apply a randomized sample and strict regulates in relation to the utilization of statins in order to avoid and control Alzheimer’s Disease. The recommended research hopes to load this important research distance and perform a clinical study that compares the development of Alzheimer’s Disease between patients that use statins and an organization that does not work with statins for the specified length of time. These two groups will not be applying statins pertaining to control of coronary artery disease, to eliminate any kind of confounding parameters that may be a consequence of CAD and Alzheimer’s. Patients will be given statins to get the sole purpose of preventing and/or controlling Alzheimer’s disease.
The objective of the proposed research is to provide reliable analysis that investigates the potential for make use of statins to manage Alzheimer’s Disease. The research will probably be conducted applying strict medical controls and under the direction of older staff. This kind of research will provide valuable insight into the validity of employing statins in order to avoid and control the development of Alzheimer’s Disease in patients who are at exposure to possible developing that.
The most important contribution of this exploration will be the exploration of statin use to get control of Alzheimer’s Disease. A very good theoretical basis exists pertaining to the advice that Alzheimer’s patients may well benefit, as a result of decreased hypercholesteria production. However , thus far, much of the supposition about the potential to work with statins associated with Alzheimer’s Disease is largely theoretical. Conflicting info exists regarding the use of statins in Alzheimer’s patients, along with warnings that a lot of may cause potential harms. This information will have to be considered in the analysis design. This research will certainly contribute valuable information to the existing body system of study regarding the usage of statins to regulate Alzheimer’s Disease.
References
Algotsson, a. Winblad, B. (2004). Patients with Alzheimer’s Disease May Be Specifically Susceptible to Adverse Effects of Statins. Dement Geriatr Cogn Disord. 17: 109-116. PubMed.
Hoglund, K. Blennow, K. (2007). Effect of HMG-CoA reductase blockers on? -amyloid peptide amounts: Implications intended for Alzheimer’s disease. CNS prescription drugs. 21 (6): 449-462. PubMed.
Jick, H., Zornberg, G., Jick, S. et ing. (2000). Statins and the likelihood of dementia
The Lancet. 356 (9242): 1627-1631 PubMed
Li, G., Higdon, R., Kukull W. ou al. (2004). Statin therapy and risk of dementia inside the elderly: a community-based potential cohort study. Neurology. 63 (9): 1624-1628. PubMed.
Li, G., Larson, E. Sonnen, J. ou al. (2007). Statin healing is associated with lowered neuropathologic adjustments of Alzheimer disease. Neurology. 69 (9): 878-875. PubMed.
Meske, Versus., Albert, Farreneheit., Richter, Deb. et ‘s. (2003). Blockade of HMG-CoA reductase activity causes within microtubule-stabilizing necessary protein tau by way of suppression of eranylgeranylpyrophosphate formation: implications to get Alzheimer’s disease. Eur M. Neurosci. 18 (1): 93-102. PubMed.
Riekse, R., Li, G., Petrie, E. et al. (2006). Effect of statins on Alzheimer’s Disease biomarkers in cerebrospinal fluid. M Alzheimers Dis. 10 (4): 399-406. PubMed.
Reiss, a. Wirkowski, At the. (2007). Position of HMG-CoA reductase blockers in nerve disorders: progress to date. Medicines. 67 (15): 2111-2120. Medline.
Sparks, M. (2002). HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer’s disease and why it would be ill-advise to work with
